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KMID : 0624620100430050337
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BMB Reports
2010 Volume.43 No. 5 p.337 ~ p.343
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Comparative analysis of fat and muscle proteins in fenofibratefed type II diabetic OLETF rats: the fenofibrate-dependent expression of PEBP or C11orf59 protein
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Hahm Jong-Ryeal
Ahn Jin-Sook
Noh Hae-Sook
Baek Seon-Mi
Ha Ji-Hye
Jung Tae-Sik
An Yong-Jun
Kim Duk-Kyu
Kim Deok-Ryong
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Abstract
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Fenofibrate, an agonist of PPARα, plays an important role in activating many proteins catalyzing lipid metabolism, and it also has a considerable effect on improvement of insulin sensitivity in the diabetic condition. To investigate fenofibratedependent expression of peripheral tissue proteins in diabetes, we analyzed whole muscle or fat proteins of fenofibrate-fed OLETF rats, an animal model of type II diabetes, using 2-dimensional gel electrophoresis. We found that many proteins were specifically expressed in a fenofibrate-dependent manner in these diabetic rats. In particular, a functionally unknown C11orf59 protein was differentially expressed in the muscle tissues (about 5-fold increase) in fenofibrate-fed OLETF rats as compared to control rats. Additionally, the signal proteins phosphatidylethanolamine binding protein and IkB interacting protein were differentially regulated in the fenofibrate-treated adipose tissues. We suggest here that these proteins might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARα activation.
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KEYWORD
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C11orf59, Fenofibrate, OLETF rats, PEBP, PPARα, Proteomics
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